ISSN 2148-4902
e-ISSN 2536-4553

Volume : 6 Issue : 2 Year : 2019

Lipid profile atherogenic indeces and their relation of epicardial fat thickness and carotid intima media thickness in Celiac disease [North Clin Istanb]
North Clin Istanb. Ahead of Print: NCI-54936 | DOI: 10.14744/nci.2019.54936  

Lipid profile atherogenic indeces and their relation of epicardial fat thickness and carotid intima media thickness in Celiac disease

Zuhal Çalışkan1, Kenan Demircioglu2, Süleyman Sayar1, Resul Kahraman1, Ozge Caklili2, Fatma Betül Özcan2, Osman Köstek3, Omer Faruk Baycan2, Hamdi Levent Doğanay1, Mustafa Caliskan2
1Sağlık Bilimleri University, Ümraniye Education and Reaserch Center, Gastoenterology department, İstanbul, Turkey
2İstanbul Medeniyet University, Göztepe Education and Reaserch Ceenter, Cardiology and Internal Medicine departments, İstanbul, Turkey
3Trakya University, Oncology department, Edirne, Turkey

INTRODUCTION: Aim: In this study we aimed to investigate presence of subclinical atherosclerosis with measuring epicardial fat thickness (EFT) and carotid intima media thickness (c-IMT), to evaluate low level inflammation with hsCRP and to evaluate whether there is a relationship between lipid profile, atherogenic indices and hsCRP with these subclinical atherosclerosis markers in patients with celiac disease (CD).

METHODS: After exclusion criteria and inclusion criteria were applied 31 patients with celiac disease (24 female: mean age 39.4 ± 12.3 years), 32 healthy controls (21 female, mean age: 39.5 ± 4.4) 63 cases were recruited Subclinical atherosclerosis was evaluated with EFT with transthoracic echocardiography and cIMT with ultrasonography. Inflammatory markers including erythrocyte sedimentation rate (ESR), high sensitive C reactive protein (hsCRP) and lipid profile was recorded. Also atherogenic indices were calculated: Castelli risk index I and II (TG/HDL-c and LDL-c/HDL-c, respectively), atherogenic index of plasma (AIP; Logarithm TG/HDL-c), non HDL-c (TG-HDL-c) and atherogenic coefficient (AC; non-HDL-c/HDL-c).

RESULTS: Epicardial fat thickness was significantly higher in CD group (0.49 ± 0.10 vs 0.49 ± 0.09; p value: 0.02). Although C-IMT was higher in the patient group, it did not reach statistical significance (0.51 ± 0.08, 0.47 ± 0.08; p value: 0.10).HDL cholesterol level was found significantly lower (42.0 ± 8.8 vs. 50.0 ± 13.7; p value: 0.01), and the plasma atherogenic index was found significantly higher in the patient group (0.98 ± 0.50 vs. 0.62 ± 0.64; p value: 0.02). Hs-CRP (3.51 ± 3.18 vs. 1.92 ± 1.40; p value: 0.02) and erythrocyte sedimentation rate (17.2 ± 12.8 with 9.7 ± 3.1; p value: 0.01) were found to be significantly higher in CD group.While there was a significant positive correlation between epicardial fat thickness and hs-CRP (r: 0.453; p value: 0.01), there was a significant negative correlation between cIMT and HDL-cholesterol (-0.339; p value: 0.05), significant positive correlation with the other components of the atherogenic index was found.
DISCUSSION AND CONCLUSION: Atherosclerosis risk has been increased in patients with CD. Chronic inflammation may be responsible for this increase along with atherogenic indices.

Keywords: Celiac disease, atherogenic dyslipidemia, cIMT, epicardial fat thickness

Corresponding Author: Zuhal Çalışkan

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